By M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, Petra Böhm (eds.)
After 3 volumes on adenoviruses in 1995 the earlier years have visible fast development within the box of adenovirus study. additionally, adenoviruses have attracted huge curiosity as vectors in gene move regimens.
Read or Download Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions PDF
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Extra resources for Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions
Nevertheless, they also point out possible base protein interactions with other cell components, downstream from the internalization event. The identification of physical partners of penton components was attempted by panning a phage-display peptide library (HONG and BOULANGER 1995). Some of the results of this study suggested that both fiber and base could interact with phage bearing the hexapeptide with a sequence similar to that of the conserved motif found in human fibronectin. It is known that cells attach to fibronectin through aSpl integrin and data exist to suggest that integrin aSp 1 may act as an alternative secondary adenovirus receptor (DAVISON et al.
The extract of the transfected cells was separated by polyacrylamide gel electrophoresis and the expression is shown by Western blot with anti-c-myc (left panel). A similar membrane was overlayed with Ad3 dodecahedron base and analyzed with anti-dodecahedron antibody (right panel). 1994). It was shown that the longer fiber, but not the shorter one, interacts with CAR, a protein that is a cell receptor for several human serotypes (ROELVINK et al. 1998). However, the enteric tropism of Ad40 and Ad41 cannot be explained by the interaction of the long fiber with ubiquitously expressed CAR.
As an example, interaction with RhoGDI la is shown in Fig. 7. When using fibers of different serotypes for membrane overlay we found that the majority of partners of Ad41 short fiber are able to interact also with the Ad41 long fiber as well as with fibers of Ad3 and Ad2. At present we are studying the specificity of these interactions with the aim of identifying cellular partners specific for the Ad41 short fiber, most probably involved in the determination of enteric tropism of this serotype.