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By C. Meyers

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Prior reported median survival was shorter than 6 months, and a poor performance status and absence of HAART before PEL diagnosis was found to be independently associated with a weaker clinical outcome in the French study. FEATURES OF PEL PEL is a distinct, high grade B-cell NHL characterized by pleural effusion, pericardial effusion, and/or ascites, generally in an HIV-infected individual, but has been described in elderly individuals with chronic heart or liver disease. 271 TREATMENT OF PEL Simonelli and colleagues,272 in a retrospective study with 277 patients with HIV infection and systemic lymphoma, had 11 individuals in the group that were classified in the PEL category.

These results confirmed that EBV may have a contributory role in the oncogenesis of leiomyosarcomas. 6,136,137 Biggar and colleagues135 used an AIDS-cancer registry and found that leiomyosarcomas appear to occur several years after AIDS onset, with three of the four cases occurring 33–76 months after AIDS diagnosis. 2. AIDS Malignancies 35 The relative risk of leiomyosarcoma during the time period 2–5 years after AIDS diagnosis was 1,915 (95% CI, 232–6,915). Granovsky and colleagues,138 in a retrospective analysis of cancer cases from the Children’s Cancer Group and National Cancer Institute, found that 11 among 64 children had leiomyosarcomas, representing 17% of all tumors and second behind NHL.

Chemotherapy Regimens for AIDS-Related PCNSL Most responders received antiretrovirals including protease inhibitor 3 patients received no HAART and 2 received AZT for <3 months No HAART No HAART HAART vs no HAART 2. 35 McGowan and Shah43 were the first to describe a case of remission maintained for over 2 years in an individual who had PCNSL after treatment with HAART alone. Hoffmann and colleagues,44 in a retrospective analysis, showed that survival time of patients receiving HAART in addition to RT differed significantly from those receiving RT or palliative care alone.

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