By André Bryskier
Annotation Antimicrobial brokers: Antibacterials and Antifungals is an important revision of an unique French reference released by means of Ellipses in 1999. bargains 1000's of antibiotics and antimicrobial compounds: in improvement, experimental, and in useProvides a radical replace of the unique French variation released in 1999, plus severe new materialPresents finished assurance of chemistry and synthesis, category, constitution & ndash;activity relationships, mechanisms of motion and resistance, breakpoints, in vitro/in vivo actions, epidemiology, pharmacokinetics, metabolism, and adversarial eventsFeatures over 1,200 illustrations, over 1,500 tables, and greater than 3,000 referencesPresents new, vast chapters protecting helicobacter pylori and methicillin & ndash;resistant Staphylococcus aureus (MSRA). �Read more...
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Extra resources for Antimicrobial agents : antibacterials and antifungals
From this basic structure, the semisynthesis of ␣-aminocephalosporins resulted in cephaloglycin. Among the ␣-aminocephalosporins, the most active molecule in vitro is cefprozil, which possesses antibacterial 8 ■ ANTIMICROBIAL AGENTS: ANTIBACTERIALS AND ANTIFUNGALS activity and a more advantageous pharmacokinetic proﬁle than that of cefaclor. Several oral cephalosporins are prodrugs, such as cefotiam hexetil, cefuroxime axetil, cefteram pivoxil, cefetamet pivoxil, cefcamate pivoxil, cefdaloxime penxetil, cefditoren pivoxil and cefpodoxime proxetil.
4. Macrolides Macrolides are antibiotics characterized by a central lactone nucleus of 14 to 16 atoms, to which is attached one (or more) amino or neutral sugars. Erythromycin was described by J. M. McGuire in 1952 and obtained from the fermentation of Saccharopolyspora erythraeus. Its structure was elucidated in 1957 by D. F. Wiley et al. The different molecules 10 ■ ANTIMICROBIAL AGENTS: ANTIBACTERIALS AND ANTIFUNGALS have gradually been described and extracted by fermentation from various Streptomyces spp.
THE PENCILLIN ERA From 1945, research in the ﬁeld of antibacterial chemotherapy followed two directions: (i) synthetic antibacterial agents not found in nature and (ii) antibiotics extracted from the fermentation of molds, actinomycetes, and other bacterial genera. 1. Antibiotics of Fungal Origin The prototype of antibiotics of fungal origin is penicillin. The second great family of antibiotics extracted from molds is that of the cephems. 1. The Discovery of Penicillin In 1729, Pier Antonio Micheli, in his work Nova plantarum genera, described the penicillia, and at the same time it was accepted that Linné’s taxon Mucor crustaceus (1742) comprised certain penicillia.