By D R Hawkins
Now in its 7th impressive quantity, Biotransformations has develop into tested as a special and critical resource for these concerned with the invention and improvement of latest compounds. It largely covers the medical literature for the interval 1987 to 1994. The sequence offers an entire survey of the biotransformations, in vertebrates, of the subsequent: prescribed drugs; agrochemicals; nutrients ingredients; environmental chemical substances; business chemical compounds. Biotransformations offers a prepared method of getting access to info at the identified pathways for the biotransformation of structurally-related compounds. Key sensible teams offer an index-related method for retrieving details on compounds of curiosity. a different index permits the retrieval of examples of particular biochemical reactions which could have wider software. each one quantity corresponds approximately with the clinical literature released in the course of a calendar yr. every one quantity includes a overview bankruptcy which discusses examples of novel biotransformations, species modifications, stereochemical elements and mechanisms of toxicity linked to particular biotransformations. learn more... summary: Now in its 7th notable quantity, Biotransformations has turn into demonstrated as a distinct and significant resource for these concerned with the invention and improvement of latest compounds. It greatly covers the clinical literature for the interval 1987 to 1994. The sequence presents an entire survey of the biotransformations, in vertebrates, of the next: prescribed drugs; agrochemicals; nutrients ingredients; environmental chemical substances; business chemical compounds. Biotransformations offers a prepared means of having access to info at the identified pathways for the biotransformation of structurally-related compounds. Key useful teams offer an index-related technique for retrieving info on compounds of curiosity. another index permits the retrieval of examples of particular biochemical reactions that could have wider program. each one quantity corresponds approximately with the medical literature released in the course of a calendar yr. each one quantity encompasses a evaluation bankruptcy which discusses examples of novel biotransformations, species variations, stereochemical points and mechanisms of toxicity linked to particular biotransformations
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Extra info for Biotransformations : a survey of the biotransformations of drugs and chemicals in animals. Vol. 7
Two pyridinium metabolites (138) and (139) were identified as urinary metabolites but these were only detected in brain tissue of animals treated with the dehydration product (see also Vol. 5, pp. 266-267). It is postulated that the nitrosourea (140) degrades to an intermediate 19 isocyanate (141) in vivo which subsequently reacts with nucleophilic entities such as glutathione. In a recent study evidence for this pathway has been investigated by analysis of bile and urine samples from rats for the glutathione and corresponding mercapturic acid metabolites (p.
S CH3N=C= S CH3,NKS 2 w CH3NHC-SNa' yHCOCH3 CH3NHCSCH2CHC02H Lj I CH3 (152) (153) (1 54) (155) Methyl diethyldithiocarbamate (156) is a reported intermediate in the metabolism of disulfiram. A known metabolite of this compound is the thiocarbamate (157). On incubation of (156) with rat liver microsomes two novel major metabolites were identified resulting from oxidation at the two 21 sulfur atoms respectively (p. 92). The sulfoxide (158) is the presumed intermediate to the thiocarbamate while the alternative sulfoxide (159) is probably also a reactive intermediate subject to attack by nucleophiles.
It is believed that the mercapturic acid is the first example of the in vivo addition of glutathione to a triple bond. It was demonstrated that co-administration of Na;’SO4 to rats resulted in incorporation of 3sS into the sulfonic acid metabolite and proposed that this involved addition of sulfite, produced by microbial reduction to sulfate, to a cyclopentadienone. 11 A n unusual series of sulfonic acid metabolites are also formed from the herbicide S-23121 (86) in rats (p. 154). Three of these metabolites (87)-(89) were phenols derived by 0-dealkylation and addition of sulfite to the double bond.