By Bernd-Dietrich Katthagen
Congenital and bought bone defects represent a crucial challenge of traumatology and orthopedics. to be able to medication those defects it's always essential to replenish the bones operatively with appropriate elements. lately, so-called bone substitutes (collagen, gelatine, bone matrix, calcium phospate, hydroxyapatite) have additionally been suggested. Following an introductory presentation of bone regeneration and transplants, those substitutes are mentioned the following in a accomplished survey of the literature. specific consciousness is given to the importance of mineral substance corresponding to hydroxyapatite, in order to absolutely discover a position in bone surgical procedure due to its amazing bioactivity and biotolerance. The implants tested also are of value for maxillofacial surgical procedure and dentistry. The histologic ideas within the staining of undecalcified bone arrangements and in histomorphometry are offered in a unique chapter.
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Additional info for Bone Regeneration with Bone Substitutes: An Animal Study
1969) found that, out of 177 solitary bone cysts which were treated by curettage and filling with freeze-dried allogenic spongiosa transplants, 55% of the cases healed completely, while 45% had a recurrence, with 36% having to undergo a second operation. In spite of this high relapse rate, they considered the technique of filling the bone cysts with freeze-dried allogenic bone transplants to be suitable. In a later publication, Spence et al. (1976) described work with freeze-dried ground allogenic bone transplants, and reported healing in 88% of all cases.
While Salama (1974) at first used bare Kiel bone splinters in man, he later (1983) reported clinical success with Kiel bone splinters which had been impregnated with autogenic red bone marrow, describing 110 implants in 98 patients. In summary, one can say that the usefulness of the Kiel bone splinter is at least very controversial, even though limited success has been reported recently, and that, worldwide, it is hardly used any longer. The next chapter will deal with the actual subject of this project, namely with bonereplacement materials.
After 1 month they observed regenerated bone between the bony stroma and the implant. The implant was in direct contact with the regenerated bone and not separated by an intermediate layer of connective tissue, and was being resorbed by multinucleated macrophages. After 6 months, 60% of the implant had been replaced by regenerated bone. Regenerated bone was observed in the macrophages and the resorbed zones ofthe implant. Peelen et al. concluded that apatite ceramics were good bone-replacement materials.