Download Combating the Threat of Pandemic Influenza: Drug Discovery by Paul F. Torrence PDF

By Paul F. Torrence

Drug discovery for influenza antivirals

Priorities for fighting pandemic influenza contain speedy detection and id, the short management of accessible medications to regard the an infection, the advance of latest antivirals, and the advance of vaccines. seeing that lead-time might be required to provide a good vaccine, antivirals could function a key first defensive position in containing an epidemic. various antivirals, appearing via various mechanisms, could aid remain the improvement of resistant viruses. therefore, drug discovery for influenza antivirals is a vital public health-related endeavor.

With chapters contributed by means of major foreign experts, this consultant will get readers in control at the most up-to-date advances and applied sciences in varied ways to drug discovery, covering:
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present antivirals, together with widely potent anti-respiratory virus agents
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the improvement of high-throughput screening assays
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IFN resistance
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the improvement of nucleic acid-based antiviral drugs
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Antiviral RNAi thoughts focusing on influenza virus
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different promising antiviral drug discovery strategies

struggling with the specter of Pandemic Influenza: Drug Discovery methods consolidates the most recent info on assorted techniques into one complete source. it truly is a useful, hands-on reference for researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health.Content:
Chapter 1 current Influenza Antivirals: Their Mechanisms of motion and capability within the Face of Avian Influenza (pages 1–37): Erik De Clercq
Chapter 2 improvement of High?Throughput Screening Assays for Influenza (pages 38–72): Diana L. Noah, E. Lucile White and James W. Noah
Chapter three Mechanisms of IFN Resistance by way of Influenza Virus (pages 73–97): Heather J. Ezelle and Bret A. Hassel
Chapter four largely powerful Anti?Respiratory Virus brokers (pages 98–125): Shiro Shigeta
Chapter five present prestige on improvement of Nucleic Acid?Based Antiviral medicinal drugs opposed to Influenza Virus an infection (pages 126–147): Jonathan P. Wong, Mary E. Christopher, Murray Cairns, L.?Q. sunlight, Roderic M. ok. Dale and Andres M. Salazar
Chapter 6 Antiviral RNA Interference concepts concentrating on Influenza Virus and different breathing Viruses (pages 148–165): Joost Haasnoot and Ben Berkhout
Chapter 7 Promising Antiviral Glyco?Molecules from an fit to be eaten Alga (pages 166–182): Toshimitsu Hayashi, Kyoko Hayashi, Kenji Kanekiyo, Yuko Ohta, Jung?Bum Lee, Minoru Hashimoto and Takahisa Nakano
Chapter eight Rational layout of an Anti?Adhesion Drug for Influenza (pages 183–208): Nicolai V. Bovin and Alexandra S. Gambaryan
Chapter nine figuring out Influenza Neuraminidase Inhibitors utilizing Quantitative Structure–Activity courting (QSAR) versions (pages 209–225): Rajeshwar P. Verma and Corwin Hansch
Chapter 10 Peptide Inhibitors concentrating on Virus?Cell Fusion at school I Enveloped Viruses (pages 226–246): George F. Gao
Chapter eleven Novel Influenza Therapeutics (pages 247–264): Laura M. Aschenbrenner, Nicole Pelletier, Mang Yu and Fang Fang

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De Clercq, E. Heterocyclic rimantadine analogues with antiviral activity. Bioorg. Med. Chem. 2003, 11, 5485–5492. 28 EXISTING INFLUENZA ANTIVIRALS 22. ; Foscolos, G. ; Kolocouris, N. Heterocyclic rimantadine analogues with antiviral activity. Bioorg. Med. Chem. 2006, 14, 3341–3348. 23. Belshe, R. ; Smith, M. ; Hall, C. ; Hay, A. J. Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection. J. Virol. 1988, 62, 1508–1512. 24. Hayden, F. G. Antiviral resistance in influenza viruses—Implications for management and pandemic response.

Hamblin, J. ; Hart, G. ; Inglis, G. ; Jones, H. ; McConnell, D. ; Mason, A. ; Owens, I. ; Reece, P. ; Shanahan, S. ; Wu, W. ; Tucker, S. P. Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen. Antimicrob. Agents Chemother. 2004, 48, 4542–4549. 87. Sidwell, R. ; Huffman, J. ; Khare, G. ; Allen, L. ; Witkowski, J. ; Robins, R. K. Broad-spectrum antiviral activity of virazole: 1-β-Dribofuranosyl-1,2,4-triazole-3-carboxamide. Science 1972, 177, 705–706.

Dis. 2006, 193, 1626–129. 29. Shea, K. M. Shift shown in influenza A adamantane resistance. JAMA 2006, 296, 1585–1587. 30. De Clercq, E. Antivirals and antiviral strategies. Nature Rev. Microbiol. 2004, 2, 704–720. 31. Moscona, A. Neuraminidase inhibitors for influenza. N. Engl. J. Med. 2005, 353, 1363–1373. 32. Matrosovich, M. ; Matrosovich, T. ; Roberts, N. -D. Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium. J. Virol. 2004, 78, 12665–12667.

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