By G. John Stanton, S. Baron (auth.), Abner Louis Notkins M.D., Michael B. A. Oldstone M.D. (eds.)
The present proliferation of clinical info makes it tough for even the main diligent reader to maintain with the newest advancements in his/her personal box, not to mention different parts of curiosity. assessment articles are one resolution, yet they too became so voluminous and precise that they typically defeat the aim for which they have been meant. we have now tried to ease this challenge through the use of a special structure. during this quantity on thoughts in Viral Pathogenesis, now we have assembled a chain of mini-reviews/editorials, 1,000 to 2,000 phrases in size. every one is a pithy distil lation of the state of the art with emphasis on present considering and unifying ideas instead of a compendium of the literature. The fifty three articles, all written by means of lively employees of their respective fields, are geared up systemati cally in order that the booklet will offer busy investigators, academics and scholars of updated info in a really short and simply learn a conceptual center capable shape. moreover, the authors have tried to spot unresolved difficulties and element to destiny directions.
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Additional info for Concepts in Viral Pathogenesis
Paramyxoviruses This large group of viruses includes the parainfluenza viruses types 1 to 5, mumps, measles, canine distemper, and Newcastle disease viruses. There are two glycoproteins on the surface of paramyxoviruses: HN, which has hemagglutinating (receptor binding) and neuraminidase activities, and F, which is involved in membrane fusion. The F protein is synthesized as a biologically inactive precursor, Fo, which may be cleaved by a host protease to yield two disulfide-bonded polypeptides, FI and F2 [2-4].
Identification of the antiviral activity as interferon and characterization of the human effector cells subpopulation. J Exp Med 147:1299-1313 18 Paolo Casali and Giorgio Trinchieri 2. Trinchieri G, Santoli D (1978) Antiviral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cell to lysis. J Exp Med 147:1314-1333 3. Welsh RM (1981) Natural cell-mediated immunity during viral infections.
Emphasis is placed on those viruses for which cleavage by host proteases has been shown to be a major determinant of virulence. , on paramyxoviruses and myxoviruses [II. Paramyxoviruses This large group of viruses includes the parainfluenza viruses types 1 to 5, mumps, measles, canine distemper, and Newcastle disease viruses. There are two glycoproteins on the surface of paramyxoviruses: HN, which has hemagglutinating (receptor binding) and neuraminidase activities, and F, which is involved in membrane fusion.